Grinding, Melting and Reshaping of EoL Thermoplastic Polymers Reinforced with Recycled Carbon Fibers

This article assesses the technical feasibility of a recycling process based on grinding, melting and re-shaping of carbon fibers (CFs) reinforced thermoplastic polymers, in order to obtain new products that can be introduced in different markets, depending on mechanical properties retained. The idea at the basis of our study is that this kind of recycling process lies at the edge of the stages of recycling and re-use of materials, considering that the latter is preferable when considering the waste management hierarchy. Lower cost and similar mechanical strength of virgin CFs allowed the spread of recycled CFs in the automotive sector in the form of composite materials. Taking into account the Directive 2000/53/EC that sets out measures to prevent and limit waste from end-of-life (EoL) vehicles and their components, and ensures that where possible this is reused, recycled or recovered, we considered worth to investigate the recyclability of composite materials made with recycled CFs when they will reach the state of EoL materials. Considering this premise, an additional scope of this paper is therefore to provide some useful information about the possibility to perform a multiple closed loop recycling of rCF thermoplastic composites. Experiments carried out demonstrated that re-shaping of composites is technically feasible. Some square plates were produced without any setback. The mass balance of the recycling process demonstrated that about 88% of the EoL material can be recovered. Calculation of energy consumption showed that approximately 16 MJ are necessary in the treatment of 1 kg of EoL composites

The free energy principle induces neuromorphic development

We show how any finite physical system with morphological, i.e. three-dimensional embedding or shape, degrees of freedom and locally limited free energy will, under the constraints of the free energy principle, evolve over time towards a neuromorphic morphology that supports hierarchical computations in which each ‘level’ of the hierarchy enacts a coarse-graining of its inputs, and dually, a fine-graining of its outputs. Such hierarchies occur throughout biology, from the architectures of intracellular signal transduction pathways to the large-scale organization of perception and action cycles in the mammalian brain. The close formal connections between cone-cocone diagrams (CCCD) as models of quantum reference frames on the one hand, and between CCCDs and topological quantum field theories on the other, allow the representation of such computations in the fully-general quantum-computational framework of topological quantum neural networks

The Hidden Quantum Groups Symmetry of Super-renormalizable Gravity

In this paper we consider the relation between the super-renormalizable theories of quantum gravity (SRQG) studied in [arXiv:1110.5249v2, arXiv:1202.0008] and an underlying non-commutativity of spacetime. For one particular super-renormalizable theory we show that at linear level (quadratic in the Lagrangian) the propagator of the theory is the same we obtain starting from a theory of gravity endowed with {\theta}-Poincar\'e quantum groups of symmetry. Such a theory is over the so called {\theta}-Minkowski non-commuative spacetime. We shed new light on this link and show that among the theories considered in [arXiv:1110.5249v2, arXiv:1202.0008], there exist only one non-local and Lorentz invariant super-renormalizable theory of quantum gravity that can be described in terms of a quantum group symmetry structure. We also emphasize contact with pre-existent works in the literature and discuss preservation of the equivalence principle in our framework.Comment: 10 page

Interplay between curvature and Planck-scale effects in astrophysics and cosmology

Several recent studies have considered the implications for astrophysics and cosmology of some possible nonclassical properties of spacetime at the Planck scale. The new effects, such as a Planck-scale-modified energy-momentum (dispersion) relation, are often inferred from the analysis of some quantum versions of Minkowski spacetime, and therefore the relevant estimates depend heavily on the assumption that there could not be significant interplay between Planck-scale and curvature effects. We here scrutinize this assumption, using as guidance a quantum version of de Sitter spacetime with known Inonu-Wigner contraction to a quantum Minkowski spacetime. And we show that, contrary to common (but unsupported) beliefs, the interplay between Planck-scale and curvature effects can be significant. Within our illustrative example, in the Minkowski limit the quantum-geometry deformation parameter is indeed given by the Planck scale, while in the de Sitter picture the parameter of quantization of geometry depends both on the Planck scale and the curvature scalar. For the much-studied case of Planck-scale effects that intervene in the observation of gamma-ray bursts we can estimate the implications of "quantum spacetime curvature" within robust simplifying assumptions. For cosmology at the present stage of the development of the relevant mathematics one cannot go beyond semiheuristic reasoning, and we here propose a candidate approximate description of a quantum FRW geometry, obtained by patching together pieces (with different spacetime curvature) of our quantum de Sitter. This semiheuristic picture, in spite of its limitations, provides rather robust evidence that in the early Universe the interplay between Planck-scale and curvature effects could have been particularly significant.Comment: 26 pages

Influence of Carding and Pressing on Hygrothermal Properties and Fire Reaction of Hemp Fiber Nonwoven Mats

This article depicts the effect of carding and pressing on hygrothermal properties of hemp fibers nonwoven mats, trying to understand if their implementation can improve their behavior when employed as insulation materials in buildings. Hemp fibers belonging to Cannabis Sativa species and coming from local area (Apulia - Italy) were examined, then samples of carded and pressed hemp fibers nonwoven mats were prepared. According to European standards, the thermal conductivity, the vapor permeability and the fire reaction of hemp fibers samples were measured. Results were compared to each other and with those of a commercial nonwoven mat made with hemp (90 wt. %) and synthetic fibers (10 wt. %), used as reference. We observed that carded and pressed hemp fibers were characterized by a lower thermal conductivity when compared to unprocessed hemp fibers, likely because the removing of wood elements. On the other hand, not processed hemp fibers show higher breathability when compared to carded and pressed ones, as well as with respect to the commercial nonwoven mat. Moreover, it was proved that the absence of synthetic commingled fibers in hemp fibers allows a better behavior in fire reaction. At last, the improvement in terms of insulation properties of a hollow brick when filled with hemp fibers was verified, by comparing the thermal conductivities of an empty and a filled hollow brick; as expected, the filled hollow brick shows a lower thermal conductivity, underlining the effectiveness of hemp fibers as insulation material

Comparative Effectiveness of Biosimilar, Reference Product and Other Erythropoiesis-Stimulating Agents (ESAs) Still Covered by Patent in Chronic Kidney Disease and Cancer Patients: An Italian Population-Based Study

Background Since 2007 biosimilars of erythropoiesis-stimulating agents (ESAs) are available on the Italian market. Very limited post-marketing data exist on the comparative effectiveness of biosimilar and originator ESAs. Aim This population-based study was aimed to compare the effects of biosimilars, reference product and other ESAs still covered by patent on hemoglobinemia in chronic kidney disease (CKD) and cancer patients in a Local Health Unit (LHU) from Northern Italy. Methods A retrospective cohort study was conducted during the years 2009-2014 using data from Treviso LHU administrative database. Incident ESA users (no ESA dispensing within 6 months prior to treatment start, i.e. index date (ID)) with at least one hemoglobin measurement within one month prior to ID (baseline Hb value) and another measurement between 2nd and 3rd month after ID (follow-up Hb value) were identified. The strength of the consumption (as total number of defined daily dose (DDD) dispensed during the follow-up divided by days of follow-up) and the difference between follow-up and baseline Hb values [delta Hb (ΔHb)] were evaluated. Based on Hb changes, ESA users were classified as non-responders (ΔHb≤0 g/dl), responders (0Delta;Hb≤2 g/dl), and highly responders (ΔHb>2 g/ dl). A multivariate ordinal logistic regression model to identify predictors for responsiveness to treatment was performed. All analyses were stratified by indication for use and type of dispensed ESA at ID. Results Overall, 1,003 incident ESA users (reference product: 252, 25.1%; other ESAs covered by patent: 303, 30.2%; biosimilars: 448, 44.7%) with CKD or cancer were eligible for the study. No statistically significant difference in the amount of dose dispensed during the follow-up among biosimilars, reference product and other ESAs covered by patent was found in both CKD and cancer. After three months from treatment start, all ESAs increased Hb values on average by 2g/dl. No differences in ΔHb as well as in frequency of non-responders, responders and highly responders among different types of ESAs were observed in both indications of use. Overall, around 15-20% of ESA users were non-responders. Strength of treatment, but no type of dispensed ESAs was found to be predictor of responsiveness to treatment. Conclusions No difference on the effects on hemoglobinemia among users of either biosimilars or reference product or ESAs covered by patent was observed in a general population from Northern Italy, despite a comparable dispensed dose of the different ESAs during the first three months of treatment

Hsp60 Is Actively Secreted by Human Tumor Cells

Background: Hsp60, a Group I mitochondrial chaperonin, is classically considered an intracellular chaperone with residence in the mitochondria; nonetheless, in the last few years it has been found extracellularly as well as in the cell membrane. Important questions remain pertaining to extracellular Hsp60 such as how generalized is its occurrence outside cells, what are its extracellular functions and the translocation mechanisms that transport the chaperone outside of the cell. These questions are particularly relevant for cancer biology since it is believed that extracellular chaperones, like Hsp70, may play an active role in tumor growth and dissemination. Methodology/Principal Findings: Since cancer cells may undergo necrosis and apoptosis, it could be possible that extracellular Hsps are chiefly the result of cell destruction but not the product of an active, physiological process. In this work, we studied three tumor cells lines and found that they all release Hsp60 into the culture media by an active mechanism independently of cell death. Biochemical analyses of one of the cell lines revealed that Hsp60 secretion was significantly reduced, by inhibitors of exosomes and lipid rafts. Conclusions/Significance: Our data suggest that Hsp60 release is the result of an active secretion mechanism and, since extracellular release of the chaperone was demonstrated in all tumor cell lines investigated, our observations most likel

Evaluating the Priorities of the Calabria's Coast FLAGs for the Improvement of the Quality of Life of the Fisheries Communities

In this study we attempt to evaluate, using a multi-criteria decision making methodology, the priorities of the directors of the six Fishery Local Action Groups (FLAGs) in Calabria Region coastal areas on some dimensions of quality of life. More specifically, the focus is on the role of the FLAGs as a policy instrument, in the context of the Community Led Local Development (CLLD), aimed at improving the quality of life of the small fisheries communities. The results have highlighted the strengths and meaningful weaknesses of the level of the perception of the quality of life of the areas where the FLAGs operated in the previous EU programming period

Quantum gravity phenomenology at the dawn of the multi-messenger era—A review

The exploration of the universe has recently entered a new era thanks to the multi-messenger paradigm, characterized by a continuous increase in the quantity and quality of experimental data that is obtained by the detection of the various cosmic messengers (photons, neutrinos, cosmic rays and gravitational waves) from numerous origins. They give us information about their sources in the universe and the properties of the intergalactic medium. Moreover, multi-messenger astronomy opens up the possibility to search for phenomenological signatures of quantum gravity. On the one hand, the most energetic events allow us to test our physical theories at energy regimes which are not directly accessible in accelerators; on the other hand, tiny effects in the propagation of very high energy particles could be amplified by cosmological distances. After decades of merely theoretical investigations, the possibility of obtaining phenomenological indications of Planck-scale effects is a revolutionary step in the quest for a quantum theory of gravity, but it requires cooperation between different communities of physicists (both theoretical and experimental). This review, prepared within the COST Action CA18108 “Quantum gravity phenomenology in the multi-messenger approach”, is aimed at promoting this cooperation by giving a state-of-the art account of the interdisciplinary expertise that is needed in the effective search of quantum gravity footprints in the production, propagation and detection of cosmic messengers.publishedVersio

Quantum gravity phenomenology at the dawn of the multi-messenger era -- A review

The exploration of the universe has recently entered a new era thanks to the multi-messenger paradigm, characterized by a continuous increase in the quantity and quality of experimental data that is obtained by the detection of the various cosmic messengers (photons, neutrinos, cosmic rays and gravitational waves) from numerous origins. They give us information about their sources in the universe and the properties of the intergalactic medium. Moreover, multi-messenger astronomy opens up the possibility to search for phenomenological signatures of quantum gravity. On the one hand, the most energetic events allow us to test our physical theories at energy regimes which are not directly accessible in accelerators; on the other hand, tiny effects in the propagation of very high energy particles could be amplified by cosmological distances. After decades of merely theoretical investigations, the possibility of obtaining phenomenological indications of Planck-scale effects is a revolutionary step in the quest for a quantum theory of gravity, but it requires cooperation between different communities of physicists (both theoretical and experimental). This review is aimed at promoting this cooperation by giving a state-of-the art account of the interdisciplinary expertise that is needed in the effective search of quantum gravity footprints in the production, propagation and detection of cosmic messengers